A cis-Element in the 5′ Untranslated Region of the Preproinsulin mRNA (ppIGE) Is Required for Glucose Regulation of Proinsulin Translation
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چکیده
منابع مشابه
A cis-element in the 5' untranslated region of the preproinsulin mRNA (ppIGE) is required for glucose regulation of proinsulin translation.
Insulin production in pancreatic beta cells is predominantly regulated through glucose control of proinsulin translation. Previously, this was shown to require sequences within the untranslated regions (UTRs) of the preproinsulin (ppI) mRNA. Here, those sequences were found to be sufficient for specific glucose-regulated proinsulin translation. Furthermore, an element 40-48 bp from the 5' end o...
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A U-rich element in the 5' untranslated region is necessary for the translation of p27 mRNA.
Increased translation of p27 mRNA correlates with withdrawal of cells from the cell cycle. This raised the possibility that antimitogenic signals might mediate their effects on p27 expression by altering complexes that formed on p27 mRNA, regulating its translation. In this report, we identify a U-rich sequence in the 5' untranslated region (5'UTR) of p27 mRNA that is necessary for efficient tr...
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ژورنال
عنوان ژورنال: Cell Metabolism
سال: 2007
ISSN: 1550-4131
DOI: 10.1016/j.cmet.2007.02.007